The stage is initially wavy, while the second part is essentially flat. After a brief opening circuit in Chiusdino, the route crosses the Siena area, passing Murlo and Asciano, reaches Cortona and then enters Umbria, taking in the only categorised climb of the day in Poggio della Croce. After dropping into Gubbio, the road flattens and straightens out all the way to the finish.
The closing kilometres are wavy at first, then run essentially uphill. There is a sharp left-hander at the last kilometre, followed by a succession of wide bends leading into the home straight, which rises slightly with gradients nearing 4%. The finish line lies on an 8 m wide asphalt straight.