This stage is wavy and undulating, especially in the second part. Starting in Camaiore and cutting through the Pisa plain, the route passes Pisa, Ponsacco and Lajatico, and then reaches Volterra. Once in the Siena area, the stage takes in some milder or sharper undulations through Rosia, Casciano di Murlo and Monticiano (including a categorised climb in Poggio alla Croce). Past the plain of San Galgano Abbey, the route heads up towards the finish in Chiusdino.
The final kilometres run mostly uphill, with several bends. The finish sits on 7 m wide tarmac.